The LRRK2-related Roco kinase Roco2 is regulated by Rab1A and controls the actin cytoskeleton

摘要

A new pathway that controls pseudopod extension is identified. Results support a model in which Rab1A is required for chemoattractant-mediated Roco2 activation that functions through the F-actin cross-linker filamin to promote pseudopod extension.